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 Durham University spin-out company Reinnervate, which is revolutionising the way cells are grown in the laboratory, is preparing for commercial manufacture and global sales after securing 750,000 pounds funding in a deal led by NorthStar Equity Investors (NSEI), a venture capital firm specialising in early-stage high-growth technologies.
Led by Dr Stefan Przyborski, a researcher at Durham University and chief scientific officer of Reinnervate, the company has developed a polystyrene foam scaffold which enables cells to grow in 3-dimensions in a similar way to how they grow in the human body. Traditionally, cells have been grown in 2-d single layers on a flat-polystyrene substrate, either in culture vessels or flat plates containing a number of wells. Studies suggest however, that cells grown on the 3-d scaffold behave more naturally which for drug testing purposes is not only more cost effective but gives a truer reading of how the drug would perform within the body. Medical News Today
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Pistachios may help curb less-than-ideal levels of LDL "bad" cholesterol, a new study shows.
But there's a catch: if you add pistachios to your diet, you've got to cut back elsewhere to keep your calorie count steady, since gaining extra weight won't do your heart any favors.
Nuts are already known to be good for your heart when eaten in moderation as part of a low-fat diet. Since 2003, the FDA has allowed almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts to make a qualified health claim to that effect.
The new study, published in The American Journal of Clinical Nutrition, is only about pistachios. Almonds and walnuts have been featured in most of the previous nut studies, so the researchers, who included Pennsylvania State University graduate student Sarah Gebauer and Distinguished Professor Penny Kris-Etherton, PhD, put pistachios in the spotlight.
The key question: Would one or two daily servings of pistachios pack a punch against LDL cholesterol? WebMD
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Men with sleep apnea may suffer from a treatable form of erectile dysfunction caused by regular deprivation of oxygen experienced during these episodes of obstructed breathing, a new report says.
University of Louisville researchers found that, in a study of mice, one week of chronic intermittent hypoxia (CIH) -- the lack of oxygen suffered during obstructive sleep apnea syndrome (OSAS) -- resulted in a 55 percent decline in their daily spontaneous erections. After five weeks, the length of time between mice attempts at mating increased on average by 60-fold.
The findings, published in the second September issue of the American Journal of Respiratory and Critical Care Medicine, showed that when the mice went back on standard oxygen levels for six weeks, they recovered 74 percent of their original erectile function. Your Total Health
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 THE North Coast is the smoking capital of NSW, with researchers saying that widespread cannabis use could be causing more than half of young men in the area to become addicted to nicotine.
Three in five male residents aged between 25 and 34 smoked, research conducted by the North Coast Area Health Service and the University of Sydney has found.
The smoking rate in the north of the state was significantly higher than that of NSW in general, which is one in three young men.
While other regional areas recorded higher smoking rates than the state average - with 39 per cent of young men in western NSW and 34 per cent in southern NSW smokers - they did not come close to the North Coast figures. Life & Style
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 An operation offered to ease the symptoms of osteoarthritis makes no difference, say Canadian doctors.
Patients given knee arthroscopy showed no improvement beyond that provided by physiotherapy and painkillers.
Arthritis experts in the UK said some surgeons were still carrying out the operation, against national guidance.
They said New England Journal of Medicine study showed doctors still relying on the technique to treat osteoarthritis were misguided. BBC News
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And that lack of knowledge could cost you your life.
If that nagging pain in your chest just won't go away, and suddenly you feel like you're having trouble catching your breath, it's time to call 9-1-1.
Those symptoms could indicate either a heart attack or impending cardiac arrest. And waiting to see if the symptoms subside could cost you your life. USA Today
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 Sticking to a full Mediterranean diet provides substantial protection against major chronic diseases including heart disease, cancer and Parkinson's and Alzheimer's disease, according to a study published on the British Medical Journal website.
A 'score' based on adherence to the Mediterranean diet could be used as an effective preventive tool for reducing the risk of premature death in the general population, say the authors.
The Mediterranean diet from populations bordering the Mediterranean Sea has a reputation for being a model of healthy eating and contributing to better health and quality of life. It is rich in olive oil, grains, fruits, nuts, vegetables, and fish, but low in meat, dairy products and alcohol. Science Daily
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 When Claire, a pixie-faced 6-year-old in a school uniform, heard her older brother, James, enter the family’s Manhattan apartment, she shut her bedroom door and began barricading it so swiftly and methodically that at first I didn’t understand what she was doing. She slid a basket of toys in front of the closed door, then added a wagon and a stroller laden with dolls. She hugged a small stuffed Pegasus to her chest. “Pega always protects me,” she said softly. “Pega, guard the door.”
James, then 10, had been given a diagnosis of bipolar disorder two years earlier. He was attending a therapeutic day school in another borough and riding more than an hour each way on a school bus, so he came home after Claire. Until James’s arrival that April afternoon, Claire was showing me sketches she had drawn of her Uglydolls and chatting about the Web site JibJab, where she likes to watch goofy videos. At the sound of James’s footsteps outside her bedroom door, she flattened herself behind the barricade. There was a sharp knock. After a few seconds, James’s angry, wounded voice barked, “Forget it,” and the steps retreated. The New York Time
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 Two UCL academics have received prominent international awards from the European Society of Cardiology (ESC), in recognition of their work to understand and treat conditions of the heart.
Professor John Martin, Director of the UCL Centre for Cardiovascular Biology & Medicine and British Heart Foundation Professor of Cardiovascular Science, has been awarded the ESC's Gold Medal. The only other holder of this medal in the UK is Sir James Black, Nobel Laureate. Dr Paul Riley, UCL Institute of Child Health, has been awarded the Outstanding Achievement Award 2008 of the ESC Council on Basic Cardiovascular Science.
Commenting on the ESC awards, Professor Ed Byrne, Executive Dean of the UCL Faculty of Biomedical Sciences and Head of the Medical School, said: "Heart and circulatory disease is the UK's biggest killer and these awards demonstrate that UCL research is breaking new ground in the understanding and treatment of these conditions. I am delighted that the ESC has chosen to recognise the scientific endeavours of John and Paul and offer my sincere congratulations to them both." Medical News Today
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HIV is striking African-Americans with "alarming" ferocity, according to a new CDC report. Just last month, the CDC reported that the overall U.S. HIV epidemic was much worse than we'd thought. Now the CDC points to groups for whom the HIV epidemic is vastly worse: Young (aged 13-29) black men who have sex with men get HIV more often than any other age/racial group. African-American women are 15 times more likely to get HIV than are white women. African-American men are six times more likely to get HIV than are white men. Hispanic women are four times more likely to get HIV than are white non-Hispanic women. Hispanic men are more than twice as likely to get HIV than are white non-Hispanic men. Among Hispanics, men get 76% of new HIV infections. African-Americans get nearly half of all new HIV infections in the U.S. Men who have sex with men get more than half of all new HIV infections in the U.S. Among white gay/bisexual men, those aged 30-39 and 40-49 get the most new HIV infections. WebMD |
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 The rise in antibiotic resistance is reaching worrying levels, experts say.
The Health Protection Agency said while the focus on infections such as MRSA had been largely successful, new trends in other bugs were now posing a threat.
For instance, 12% of bloodstream infections by E. coli in England, Wales and Northern Ireland now show some signs of not responding to drugs.
The HPA said the NHS must be careful over antibiotic use and urged industry to look into developing new drugs. BBC News
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 Scientists have detected previously unnoticed chemical signals that individual cells in the immune system use to communicate with each other over short distances.
The signals the researchers detected originated in dendritic cells – the sentinels of the immune system that do the initial detection of microscopic invaders – and were received by nearby T-cells, which play a number of crucial roles in the immune system, including coordination of attacks on agents that cause disease or infection.
The chemical signals cells exchange when they come into contact have been studied extensively. But it has not been possible to detect chemical messages that travel between cells that are nearby but not in contact – called paracrine signals – because they are highly localized and they are produced in concentrations that have been below detection levels. A new technology, called a multi-trap nanophysiometer, was required to demonstrate the existence of non-contact signaling. This is one of the first microfluidic devices that has been applied successfully to the study of cell-to-cell signaling in the immune system. Science Daily
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